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Cells treated with bicalutamide in galactose medium did not have significantly reduced ATP content compared with glucose-conditioned cells, indicating that bicalutamide has no direct mitochondrial liability in HepG2 cells at the concentrations used (Figure 5C).

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The first LHRH antagonist, abarelix (Plenaxis), was approved by the US Food and Drug Administration (FDA) for advanced, symptomatic prostate cancer in late 2003.

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