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Cells treated with bicalutamide in galactose medium did not have significantly reduced ATP content compared with glucose-conditioned cells, indicating that bicalutamide has no direct mitochondrial liability in HepG2 cells at the concentrations used (Figure 5C).

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Microsoft, Redmond, WA) database that serves as the basis for the results reported herein (Appendix 8).

The first LHRH antagonist, abarelix (Plenaxis), was approved by the US Food and Drug Administration (FDA) for advanced, symptomatic prostate cancer in late 2003.

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